Principal Investigator: Understanding Social Affiliative Deficits in Psychopathology. NIMH 1R01MH110462. Dates: 08/2016 to 05/2020. Budget: $2,222,490 (total costs).
GRANT ABSTRACT: As defined by the Research Domain Criteria (RDoC) Social Processes Workshop, affiliation is the engagement in positive social interactions with others. The desire to affiliate has been described as a fundamental human motivation. However, impairments in the drive to affiliate occur across multiple clinical disorders and these affiliative impairments have devastating consequences for individuals, their family members, and society. Despite the major clinical significance of impairments in social affiliation, the factors that contribute to affiliative impairment are poorly understood. We propose a multi-method assessment of a large and diverse clinical sample to examine how social affiliative deficits are associated with a) the social regulation of neural systems relating to emotion as assessed through a novel fMRI paradigm for studying the in vivo social regulation of emotion in the context of affiliative relationships, b) neural processes associated with social reward, c) learning of the positive affective value of others, and d) behavioral affiliative skills. Consistent with the RDoC, this application will include assessment of affiliation processes across units of analyses including circuits, behavior, and self-report within a transdiagnostic sample of individuals with psychotic disorders. With regard to the study of neural systems, a powerful mechanism that may underlie the motivation for social contact is the social regulation of emotion, particularly the social regulation of threat responding. We propose the use of a novel paradigm to create affiliative relationships within the lab and subsequently will examine how this affiliative relationship regulates emotional responding to a stressor (a key function of affiliative relationships) within an fMRI scan. Specifically, we will examine the hypothesis that affiliative deficits are associated with the failure of social contact to down regulate neural activity in the context of a stressor. In addition to the benefits that affiliation provides when responding to threat, the motivation for social relationships may derive from activation of neural systems involved in reward. We will also explore the contribution of reward circuits to affiliative impairment using both social and monetary reward paradigms. Beyond neural responding, the proposed study will examine how individuals form behavior-based impressions of others in ways that may facilitate or impede social affiliation. We will examine the hypothesis that deficits in affiliation are associated with impairments in the ability to use behavior-based person information to form positive impressions concerning the affective value of others in the social environment. Finally, behavioral social skills form the basis for effective communication and are thought to be critical to social competence. We will examine the hypothesis that impairments in social affiliation are specifically related to deficits in behavioral affiliative skills. The proposed study will provide an integrative perspective to advance our understanding of the neural and behavioral factors that give rise to impairments in social affiliation within clinical populations and this research will provide insights that will inform the development of interventions to address such impairments in affiliation.
Co-Principal Investigator (with Dr. Shackman and Dr. Choe, Co-PIs): Understanding the role of negative affect in psychosis using multimodal imaging and wearable trackers. University of Maryland Brain and Behavior Initiative Seed Grant.
SUMMARY: The goal of this pilot study is to use an innovative combination of cutting-edge approaches—including advanced multi-modal neuroimaging techniques and smartphone-based tracking technologies to rigorously identify anxiety-relevant brain circuits in the lab and understand, for the first time, their relevance to the expression of negative affect and paranoia in psychosis. Ecological momentary assessment (EMA) will be used over 7 days to examine the hypothesis that anxiety-relevant brain circuits and paranoia are associated with (a) pervasively elevated negative affect (e.g., worry, anger), (b) increased reactivity (e.g. elevated paranoia) and ‘mood spillover’ following exposure to unfamiliar others, mild stressors, or urban environments, and (c) decreased or problematic social engagement. In addition to EMA the study will use actigraphy to characterize sleep patterns and examine the contribution of sleep disturbances to more severe paranoia and increased reactivity of anxiety-relevant brain circuits.
Co-Investigator: Improving Negative Symptoms and Community Engagement in Veterans with Schizophrenia (PI: Bennett). Veteran Administration RR&D 1I01RX001293-01A2), 06/01/15 – 05/31/20.
GRANT ABSTRACT: Anticipated Impacts on Veteran’s Healthcare: Negative symptoms are a central and enduring feature of schizophrenia and are related to pervasive deficits in residential independence, occupational functioning, and quality of life for veterans living with this illness. Currently there is no effective treatment for this critical domain of the illness. As outlined in the VA Mental Health Strategic Plan, the development and implementation of strategies to enhance community functioning and promote recovery among veterans with schizophrenia is a VHA priority. This study will evaluate a tailored intervention package called Engaging in Community Roles and Experiences (EnCoRE) targeting negative symptoms in Veterans with schizophrenia. Project Background: Negative symptoms are distinct clinical features of schizophrenia that are major determinants of the poor community functioning and poor long-term outcome that characterize the disorder, as well as a major source of burden for caregivers. Recent reports document the lack of effective interventions that target the key clinical domains of negative symptoms and call for the development of interventions designed specifically to address this critical unmet treatment need. Our preliminary data on intervention development, negative symptom assessment, affective experience, and dysfunctional cognitions argues for an intervention that incorporates evidence-based treatment strategies to target affective-motivational deficits, behavioral skills deficits, and negative expectations of success as the key aspects of the illness that underlie motivation to engage in goal directed behavior. Project Objectives: This application is focused evaluating a tailored intervention package targeting negative symptoms in Veterans with schizophrenia who receive mental health services at 3 VAMCs. EnCoRE will include motivational, cognitive, and behavioral skills training strategies aimed at teaching individuals ways to (1) understand and overcome deficits in anticipatory pleasure, (2) increase intrinsic motivation for pleasant and goal directed activities, (3) reduce negative expectancies for success and performance, and (4) perform skillfully in new social situations. The primary objectives of this project are to (1) Train therapists and refine the EnCoRE manual in a preliminary trial with 10 Veterans with schizophrenia and negative symptoms; (2) Conduct a randomized clinical trial (RCT; n=108, medium effect, alpha=.05) to test the efficacy of EnCoRE in producing positive changes at post-treatment and 3-month follow-up on the primary outcomes of negative symptoms and social and community functioning; and (3) Examine qualitative interviews completed by Veterans who participated in EnCoRE and Mental Health Providers to determine aspects of EnCoRE that were perceived as more or less helpful, interesting, and valuable in order to inform a larger, multi-site implementation trial. Secondary objectives include assessing the modifying effects of cognitive ability and psychotic symptoms on intervention effectiveness, and examining recovery, self-efficacy, and program satisfaction. Project Methods: This project will include a period of training followed by an RCT with 108 participants. Participants will complete assessments at baseline, post-treatment, and 3-months. We will monitor fidelity, feasibility, and acceptability; study Veteran’s experience in the program; measure symptom and functional outcomes; and evaluate potential moderators of outcomes.
RECENTLY COMPLETED GRANTS
Project Title: Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS)
Agency: NIMH (R01 MH082839)
PI: Jack J. Blanchard
Project Title: Schizophrenia Research Training Program
Agency: NIMH (T32)
PI: Jack J. Blanchard